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dc.contributor.author Aistrup, Gary L. en
dc.contributor.author Arora, Rishi en
dc.contributor.author Patel, Heetabh en
dc.contributor.author Ramakrishna, Satvik en
dc.contributor.author Shiferaw, Yohannes en
dc.date.accessioned 2017-11-09T20:20:39Z
dc.date.available 2017-11-09T20:20:39Z
dc.date.issued 2010 en
dc.identifier.citation Biophysical Journal 98(3, Supplement 1), 21a. (2010) en
dc.identifier.issn 0006-3495 en
dc.identifier.uri http://hdl.handle.net/10211.3/197748 en
dc.description.abstract Spontaneous Ca2+ release (SCR) in the form of Ca2+ waves is responsible for cardiac myocyte depolarization and delayed afterdepolarizations (DADs) that can produce triggered beats. Whether or not a cell reaches threshold is determined by the magnitude and rate of spread of the Ca2+ wave in the cell and the resultant activation of inward current via forward mode Na-Ca exchange. In this study, we combined experimental observations with computer simulations in order to investigate the mechanisms by which the characteristics of Ca2+ wave activation influences DAD magnitude. en
dc.format.extent 1 Page en
dc.language.iso en en
dc.publisher Biophysical Journal en
dc.relation.uri doi.org/10.1016/j.bpj.2009.12.127 en
dc.rights copyright 2010 Biophyiscal Society en
dc.subject spontaneous ca2+ en
dc.subject calcium en
dc.subject cardiac myocyte deploarization en
dc.subject delayed afterdepolarization en
dc.subject adnormal caclium en
dc.title Recruitment of Multiple Spontaneous Ca2+ Release Initiation Sites Promotes Ca2+ Waves in Myocytes of Intact Rat Heart Under Conditions of Ca2+ Overload en
dc.type Article en


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