dc.contributor.author | Garfinkel, Alan J. | en |
dc.contributor.author | Karma, Alain | en |
dc.contributor.author | Qu, Zhilin | en |
dc.contributor.author | Shiferaw, Yohannes | en |
dc.contributor.author | Weiss, James N. | en |
dc.date.accessioned | 2017-11-09T20:27:02Z | |
dc.date.available | 2017-11-09T20:27:02Z | |
dc.date.issued | 2006 | en |
dc.identifier.citation | Annals of the New York Academy of Sciences 1080(1), 376-394. (2006) | en |
dc.identifier.issn | 0077-8923 | en |
dc.identifier.uri | http://hdl.handle.net/10211.3/197753 | en |
dc.description.abstract | When a cardiac cell is rapidly paced it can exhibit a beat-to-beat alternation in the action potential duration (APD) and the intracellular calcium transient. This dynamical instability at the cellular level has been shown to correlate with the genesis of cardiac arrhythmias and has motivated the application of nonlinear dynamics in cardiology. In this article, we review mathematical approaches to describe the underlying mechanisms for alternans using beat-to-beat iterated maps. We explain the development and properties of these maps, and show that they provide a fruitful framework to understand dynamical instabilities of voltage and calcium in paced cardiac cells. | en |
dc.format.extent | 19 Pages | en |
dc.language.iso | en | en |
dc.publisher | Annals of the New York Academy of Sciences | en |
dc.relation.uri | doi.org/10.1196/annals.1380.028.x | en |
dc.rights | copyright 2006 New York Academy of Science | en |
dc.subject | cardiac cell | en |
dc.subject | action potential duration | en |
dc.subject | intracellular calcium transient | en |
dc.subject | calcium | en |
dc.title | Nonlinear Dynamics of Paced Cardiac Cells | en |
dc.type | Article | en |
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