Show simple item record

dc.contributor.author Garfinkel, Alan J. en
dc.contributor.author Karma, Alain en
dc.contributor.author Qu, Zhilin en
dc.contributor.author Shiferaw, Yohannes en
dc.contributor.author Weiss, James N. en
dc.date.accessioned 2017-11-09T20:27:02Z
dc.date.available 2017-11-09T20:27:02Z
dc.date.issued 2006 en
dc.identifier.citation Annals of the New York Academy of Sciences 1080(1), 376-394. (2006) en
dc.identifier.issn 0077-8923 en
dc.identifier.uri http://hdl.handle.net/10211.3/197753 en
dc.description.abstract When a cardiac cell is rapidly paced it can exhibit a beat-to-beat alternation in the action potential duration (APD) and the intracellular calcium transient. This dynamical instability at the cellular level has been shown to correlate with the genesis of cardiac arrhythmias and has motivated the application of nonlinear dynamics in cardiology. In this article, we review mathematical approaches to describe the underlying mechanisms for alternans using beat-to-beat iterated maps. We explain the development and properties of these maps, and show that they provide a fruitful framework to understand dynamical instabilities of voltage and calcium in paced cardiac cells. en
dc.format.extent 19 Pages en
dc.language.iso en en
dc.publisher Annals of the New York Academy of Sciences en
dc.relation.uri doi.org/10.1196/annals.1380.028.x en
dc.rights copyright 2006 New York Academy of Science en
dc.subject cardiac cell en
dc.subject action potential duration en
dc.subject intracellular calcium transient en
dc.subject calcium en
dc.title Nonlinear Dynamics of Paced Cardiac Cells en
dc.type Article en


Files in this item

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


My Account

RSS Feeds