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dc.contributor.advisor De bellard, Maria en_US
dc.contributor.author Hain, Samantha
dc.date.accessioned 2019-09-04T16:28:09Z
dc.date.available 2019-09-04T16:28:09Z
dc.date.copyright 2019 en_US
dc.date.issued 2019-09-04
dc.identifier.uri http://hdl.handle.net/10211.3/213151 en
dc.description California State University, Northridge. Department of Biology. en
dc.description.abstract Chemokines are signaling proteins released by cells in response to chemical stimuli in their environment. The chemokine stromal derived factor 1 (SDF1) has been regularly studied due to its role in the growth and metastasis of multiple cancers, including melanoma. SDF1 has two known receptors: CXCR4 and CXCR7. Previous research has mainly focused on CXCR4 receptor signaling, which influences many cell responses, among them the migration of neural crest cells and the amount of receptor expression is upregulated in melanoma. CXCR7 receptor signaling is not as well studied but has been shown to influence melanocyte migration and constrain melanoma tumor growth in vivo where as CXCR4 could not. It is not known, however, how relevant CXCR7 may be in the capability of melanocyte and melanoma migration. Here, I studied the potential roles of CXCR4 and CXCR7 in melanocyte and melanoma migration in vitro by genetically silencing both receptors. My data shows that the CXCR7 receptor is more important for migratory capabilities of melanocytes and melanoma cells than the CXCR4 receptor. These findings suggest that down regulating or blocking the CXCR7 receptor through targeted therapies may show a substantial effect in melanoma treatment.
dc.description.statementofresponsibility by Samantha Hain en_US
dc.format application/pdf en
dc.format.extent 8, 52 pages en_US
dc.language.iso en_US en_US
dc.publisher California State University, Northridge en_US
dc.rights.uri http://scholarworks.csun.edu/xmlui/handle/10211.2/286 en_US
dc.subject Melanoma
dc.subject Meanocytes
dc.subject Cancer
dc.subject SDF1
dc.subject CXCR4
dc.subject CXCR7
dc.subject Movement
dc.subject Motility
dc.subject Wound
dc.subject siRNA
dc.subject.other Dissertations, Academic -- CSUN -- Biology. en_US
dc.title The Roles of CXCR4 and CXCR7 in Melanocyte and Melanoma Motility en
dc.type Thesis en
dc.date.updated 2019-09-04T16:28:10Z
dc.contributor.department Biology en
dc.description.degree M.S. en_US
dc.contributor.committeeMember Malone, Cindy en_US
dc.contributor.committeeMember Abrol, Ravinder en_US
dc.rights.license By signing and submitting this license, you the author grant permission to CSUN Graduate Studies to submit your thesis or dissertation, and any additional associated files you provide, to CSUN ScholarWorks, the institutional repository of the California State University, Northridge, on your behalf. You grant to CSUN ScholarWorks the non-exclusive right to reproduce and/or distribute your submission worldwide in electronic or any medium for non-commercial, academic purposes. You agree that CSUN ScholarWorks may, without changing the content, translate the submission to any medium or format, as well as keep more than one copy, for the purposes of security, backup and preservation. You represent that the submission is your original work, and that you have the right to grant the rights contained in this license. You also represent that your submission does not, to the best of your knowledge, infringe upon anyone's copyright. If the submission contains material for which you do not hold copyright, or for which the intended use is not permitted, or which does not reasonably fall under the guidelines of fair use, you represent that you have obtained the unrestricted permission of the copyright owner to grant CSUN ScholarWorks the rights required by this license, and that such third-party owned material is clearly identified and acknowledged within the text or content of the submission. If the submission is based upon work that has been sponsored or supported by an agency or organization other than the California State University, Northridge, you represent that you have fulfilled any right of review or other obligations required by such contract or agreement. CSUN ScholarWorks will clearly identify your name(s) as the author(s) or owner(s) of the submission, and will not make any alterations, other than those allowed by this license, to your submission. en_US


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