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Recruitment of Multiple Spontaneous Ca2+ Release Initiation Sites Promotes Ca2+ Waves in Myocytes of Intact Rat Heart Under Conditions of Ca2+ Overload
Spontaneous Ca2+ release (SCR) in the form of Ca2+ waves is responsible for cardiac myocyte depolarization and delayed afterdepolarizations (DADs) that can produce triggered beats. Whether or not a cell reaches threshold is determined by the magnitude and rate of spread of the Ca2+ wave in the cell and the resultant activation of inward current via forward mode Na-Ca exchange. In this study, we combined experimental observations with computer simulations in order to investigate the mechanisms by which the characteristics of Ca2+ wave activation influences DAD magnitude.